Tropical Journal of Pharmaceutical Research

Original Research Article | OPEN ACCESS

Effects of the combination of loxoprofen sodium and sodium hyaluronate on osteoarthritis and knee function

Yi Zou, Song Hu, Xiaozhong Yang, Weilin Wang, Honglin You, Bo Hu, Dagang Zhang

Department of Bone and Joint Surgery, Guang'an People's Hospital, West China Guang'an Hospital, Sichuan University, Guang'an, Sichuan 638000, China;

For correspondence:- Dagang Zhang Email: guangzhou_303@163.com Tel:+8613696187778

Accepted: 31 August 2022 Published: 30 September 2022

Citation: Zou Y, Hu S, Yang X, Wang W, You H, Hu B, et al. Effects of the combination of loxoprofen sodium and sodium hyaluronate on osteoarthritis and knee function. Trop J Pharm Res 2022; 21(9):2025-2030 doi: 10.4314/tjpr.v21i9.29

© 2022 The authors.
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Abstract

Purpose: To determine the treatment efficacy of the combination of loxoprofen sodium and sodium hyaluronate in osteoarthritis (OA), and its role in knee joint function.

Methods: 98 patients with OA admitted to Guang'an People's Hospital, Sichuan, China were allocated into control group (CNG, given loxoprofen sodium n, = 51) and study group (SG, given loxoprofen sodium and sodium hyaluronate, n = 47). Both groups were compared in terms of the levels of inflammatory factor, Lysholm, VAS, WOMAC scores, treatment effects, serum MDA, NO, SOD levels, adverse effects, and blood rheology indices.

Results: The study group had higher SOD levels, and higher BALP and BGP than CNG (p < 0.05). SG had lower TRACP-5b and blood rheological indices than CNG (p < 0.05). The difference in the incidence of adverse reactions was not statistically significant between the two groups (p > 0.05).

Conclusion: The combination of loxoprofen sodium and sodium hyaluronate effectively improves the function and blood rheological indices of knee joints. It reduces the occurrence of adverse reactions and the level of pain in patients with OA, and improves OA prognosis. However further clinical trials are required prior to application in clinical practice.

Keywords: Loxoprofen sodium, Sodium hyaluronate, Osteoarthritis, Knee joint function